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Blood vessel hyperpermeability and pathophysiology in human tumour xenograft models of breast cancer: a comparison of ectopic and orthotopic tumours

โœ Scribed by Karyn S Ho, Peter C Poon, Shawn C Owen, Molly S Shoichet

Book ID
119897594
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
397 KB
Volume
12
Category
Article
ISSN
1471-2407

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โœ Yuko Tsukamoto; Yukio Kato; Masako Ura; Ikuo Horii; Tohru Ishikawa; Hideo Ishits ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 274 KB ๐Ÿ‘ 2 views

## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5โ€FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5โ€FU and 5โ€F