Blood Substitutes: New Challenges

✍ Scribed by Robert M. Winslow M.D. (auth.), Robert M. Winslow M.D., Kim D. Vandegriff Ph.D., Marcos Intaglietta Ph.D. (eds.)

• Publisher: Birkhäuser Basel
• Year: 1996
• Tongue: English
• Leaves: 218
• Edition: 1
• Category: Library

✦ Synopsis

This book is not a "proceedings" volume. Rather the chapters are essays by experts in the field of blood substitutes, invited by the editors to con­ tribute to the 1996 "Current Issues in Blood Substitutes Research and Development" course given in San Diego, March 18-21. The contributors were selected because of their expertise in areas deemed by the editors to be critical to the advancement of the field. The course, as in past years, is heavily influenced by feedback from par­ ticipants, and by research in this and related fields. In addition to the didactic lectures (for which these chapters are the foundation), the course also offers the opportunity for presentation of research reports, progress reports from the various companies currently commercializing products, and round table discussions of selected subjects. Thus, we are grateful to past participants for their helpful comments. Production of a book, especially on a short timeline, is not an easy feat.

✦ Table of Contents

Front Matter....Pages i-xii
Blood Substitutes: 1995 in the Literature....Pages 1-14
Blood Substitutes: What is the Target?....Pages 15-33
Blood Flow Distribution During Shock....Pages 34-59
Blood Substitute Oxygen Carriers Designed for Clinical Applications....Pages 60-73
Interaction of Hemoglobin with Nitric Oxide and Carbon Monoxide: Physiological Implications....Pages 74-98
Biological Consequences of Cross-linked Hemoglobin in Animal Models of Surgery and Endotoxemia....Pages 99-111
Hemorrhagic Disorders After Administration of Glutaraldehyde-polymerized Hemoglobin....Pages 112-123
Microvascular Oxygen Distribution: Effects Due to Free Hemoglobin in Plasma....Pages 124-131
Experimental Simulation of Oxygen Transport in Microvessels....Pages 132-145
Carbon Dioxide Transport by Hemoglobin-Based Blood Substitutes....Pages 146-162
Non-phospholipid Liposomes: A Novel Method for the Preparation of Hemoglobin Containing Lipid Vesicles....Pages 163-184
Hemoglobin-Endotoxin Interactions....Pages 185-202
Back Matter....Pages 203-209

✦ Subjects

Hematology; Life Sciences, general; Biomedicine general; Mathematics, general