The pharmacokinetics of YH1885 were evaluated after intravenous (iv) and oral administrations of the drug to rats and dogs. The reason for the low extent of bioavailability (F) of YH1885 after oral administration of the drug to rats and the absorption of the drug from various rat gastrointestinal (G
Blood partition and protein binding of a new reversible proton pump inhibitor, YH1885
โ Scribed by Kye S. Han; Yoon G. Kim; Jong W. Lee; Myung G. Lee
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 116 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0142-2782
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## Abstract The purpose of this study was to investigate the causes for the differences observed in the pharmacokinetics of YJAโ20379โ8 in 16โweekโold spontaneously hypertensive rats (SHRs). To see if the hereditary characteristics of SHRs was the cause, 20 mg/kg of the drug was intravenously infus