Blood parameters and electrocardiogram in squeezed fish simulating the effect of net damage and recovery

A computer simulation of the food effect

A computer simulation of the food effect: Transient changes in hepatic blood flow and michaelis-menten parameters as mediators of hepatic first pass metabolism and bioavailability of propranolol

✍ H. A. Semple; Dr. Y. K. Tam; R. T. Coutts 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 744 KB

A physiological model of propranolol disposition was designed to help explain the large increase in AUC seen when the drug is administered with food. The mass balance equation for the liver compartment used Michaelis-Menten terms to describe hepatic metabolism. Previously published pharmacokinetic a