Blood levels of oxime and symptoms in humans after single and multiple oral doses of 2-pyridine aldoxime methochloride

✍ Scribed by Frederick R. Sidell; William A. Groff; Robert I. Ellin

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 516 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600580911

✦ Synopsis

Single and repeated doses of a commercially available tablet of 2-pyridine aldoxime methochloride (2-PAMCI) were given to volunteers. A single dose of 5 g. was required to produce a plasma level of 4 mcg./ml., and higher doses (to 9 g.) produced plasma levels up to 11 mcg./ml. However, there was much variation in blood levels among individuals receiving the same dose. Although it was possible to maintain blood levels of more than 4 mcg./ml. when the oxime was given in doses higher than 3 g. at 4-hr. intervals, all subjects who received multiple doses over 48 hr. had gastrointestinal symptoms. The mean urinary excretion was 20-25z of the dose administered; the plasma t0.5 was 2.7 hr. and the to.& for excretion into the urine was 2.4 hr.

Keyphrases 0 2-Pyridine aldoxime methochloride (2-PAMC1)oxime blood levels 0 Oxime levels-blood, urine 0 Pharmacological effects-2-PAMCI 0 Biological half-life-2-PAMCI 0 Dose-( 5 ) A.