Blood histamine in myelogenous leukemia

✍ Scribed by Michael B. Shimkin; Howard R. Bierman; B. V. A. Low-Beer; Priscilla M. Wheeler; Franz R. Goetzl

• Publisher: John Wiley and Sons
• Year: 1951
• Tongue: English
• Weight: 653 KB
• Volume: 4
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(195105)4:3<570::aid-cncr2820040309>3.0.co;2-3

✦ Synopsis

I N 1935, 13ai souin nnd Gddurri 1 eported a method for the extraction and pliarruacological ass'iy of a histamine-like substance in blood. Code and Ing isolated and chemically identified this substance as histamine.

T h e amount of histamine found in whole blood 01 noiirial indi\iduals, as determined by Cock's { modification of the method of Barmum and Gaddurn, ranges between 1.0 and 8.5 pg., expiessed 'is free histamine base per 100 cc. of whole blood. h mean value ol 4.0 pg. was found in 193 such deteiminations,q and an upper limit of noirrial at 10 pg. is usually accepted.

T h e blood histamine reinairis within normal range in a Iaricty of disease conditions. It may be decreased in shock and agonal states and during attacks of angioneurotic edema. It is occasionally increased u p to 20 pg. in bionchial astlinia arid oilier allergic states, cutaneous burns, eosinophilia due to various causes, and polycythcmia Vera. Levels of UIJ to 50 pg. occurred in file of 155 patients with these conditions.9 In contrast, the histamine in the blood of patients with myelogenous leukemia oiten exceeds 100 pg. Values from 100 to 1700 pg. weie reported in twenty-selen of foity-six cases. T h e observations, first rc-From the I.