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Blood glutathione as a measure of exposure to toxic compounds

✍ Scribed by P. Di Simplicio; P. Dolara; M. Lodovici

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 237 KB
Volume: 4
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550040502

No coin nor oath required. For personal study only.

✦ Synopsis

Blood and liver glutathione levels were measured under the effect of an acute exposure t o high doses of glutathionedepleting substances. Among direct-acting glutathione-depleting substances, diethyl maleate (0.3, 0.7 and 1.4 ml kg-') caused a marked reduction of both blood and liver glutathione, whereas methyl iodide (320 mg kg-') led t o a decrease in liver glutathione stores immediately and in blood stores with a longer latency. Indirectly glutathionedepleting substances, like paracetamol (0.5-1 .O g kg-' ) and styrene (250 mg kg-'), caused a reduction of liver glutathione, but not a similar reduction of blood glutathione. Blood glutathione is not a good measure of organ glutathione stores when dealing with indirect-acting glutathione-depleting substances.

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