Blood flow in the cerebral cortex during cardiac resuscitation in dogs

✍ Scribed by Raymond E Jackson; Kathleen Joyce; Steve F Danosi; Blaine C White; David Vigor; Thomas J Hoehner

• Publisher: Elsevier Science
• Year: 1984
• Tongue: English
• Weight: 332 KB
• Volume: 13
• Category: Article
• ISSN: 1097-6760
• DOI: 10.1016/s0196-0644(84)80721-0

✦ Synopsis

Regional cerebral cortical blood flow (rCCBF) in 15 large dogs was determined using the double thermistor dilution method during standard closed-chest massage (CCM), CCM with an epinephrine infusion at 30 micrograms/kg/min (CCM + Epi), and open-chest cardiac massage (OCCM). As a percentage of prearrest flow values, the rCCBF was 9.8% with CCM, 35% with CCM + Epi, and 156% with OCCM. The rCCBF was reduced significantly with CCM (P less than .005) and CCM + Epi (P less than .01). OCCM generated flows indistinguishable from prearrest values. The use of high-dose epinephrine significantly increased the rCCBF during CCM. The implications for intact neurologic resuscitation of these reductions in rCCBF with CCM are important.