Blood coagulation in cystic fibrosis: modulating inflammation?
โ Scribed by H. Ten Cate
- Book ID
- 109148298
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 71 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1538-7933
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Nitric oxide (NO) is produced from three isoforms of nitric oxide synthase (NOS), neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). Cystic ยฎbrosis (CF) patients have an increased bacterial load in the airways which stimulates iNOS and therefore NO production. Upregulation of iNOS in normal e
Recombinant human deoxyribonuclease (rhDNase) has been shown to reduce sputum viscoelasticity and to improve lung function in patients with cystic fibrosis (CF). The aim of this study was to determine whether airway inflammation would decrease after administration of rhDNase. Twenty patients with CF