Blood-brain barrier permeation in the rat during exposure to low-power 1.7-GHz microwave radiation

✍ Scribed by T. R. Ward; J. S. Ali

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 767 KB
• Volume: 6
• Category: Article
• ISSN: 0197-8462
• DOI: 10.1002/bem.2250060205

✦ Synopsis

The permeability of the blood-brain barrier to high-and low-molecular-weight compounds has been mcasured as a function of continuous-wavc (CW) and pulsed-microwave radiation. Adult rats, anesthetized with pentobarbital and injectcd intravenously with a mixture of [I4C] sucrose and 13H] inulin, were exposed for 30 min at a specific absorption rate of 0.1 Wikg to 1.7-GHz C W and pulsed (0.5-ps pulse width, 1,000 pps) microwaves. After exposure, the brain was perfused and sectioned into nine regions, and the radioactivity in each region was counted. During identical exposure conditions, temperatures of rats were measured in eight of the brain regions by a thermistor probe that did not perturb the field. No changc in uptake of eithcr tracer was found in any of the eight regions as compared with those of sham-exposed animals.