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Blood-Brain barrier permeability to γ-aminobutyric acid in hepatic encephalopathy

✍ Scribed by Mario Baraldi; Gary W. Goldstein

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
209 KB
Volume
5
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

Fuller and Hoppel (1) observed hypercarnitinemia in 20 alcoholic cirrhotic patients in contrast to previous reports (2,3) in which normal or low carniine levels were detected.

We measured serum carnitine levels by an enzymaticcolorimetric method (normal, 35 to 70 p M ) (4) in 15 HBsAg-positive nonalcoholic cirrhotics. Free and acyl carnitine levels were normal in five Child A subjects and elevated (101 f 16.5) in 10 Child B-C subjects. Only hypercarnitinemic patients were hyperglucagonemic [470 f 210; volume neutral, 50 to 250 pg per ml (by radioimmunoassay)]. No significant correlation was detected between carnitine levels and height, weight, midupper arm muscle circumference or triceps skin-fold thickness. There was a positive correlation between serum bilirubin levels (r = 0.80, p < 0.001). REFERENCES 1. Fuller RK, Hoppel CL. Elevated plasma carnitine in hepatic cir-

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