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Blood-brain barrier permeability is markedly decreased in cholestasis in the rat

✍ Scribed by Jacqueline B. Wahler; Dr. Mark G. Swain; Richard Carson; Nora V. Bergasa; E. Anthony Jones

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
621 KB
Volume
17
Category
Article
ISSN
0270-9139

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✦ Synopsis

The blood-brain-barrier plays an essential role in regulating the entrance of substances into the brain.

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## Abstract Permeability‐surface area products (PAs) of the blood‐nerve barrier (BNB) and blood‐brain barrier (BBB) to ^125^I‐labeled native bovine serum albumin (nBSA, pI ∼︁4), and to 2 cationized albumins (cBSA) of differing pI (pI ∼︁ 8 and 11), were quantitatively determined in awake rats, using