Although CD28 triggering provides an important co-stimulatory signal to T cells, blocking the CD80/CD86 -CD28 interaction with CTLA-4lg fusion protein is not sufficient for tolerance induction in vivo or in vitro. According to more recent data, interruption of the CD40 -CD154 interaction might compl
✦ LIBER ✦
Blocking the CD154–CD40 interaction with anti-CD154 antibody differentially regulates interleukin-4 synthesis in T cells and IgE production in B cells
✍ Scribed by Takehiro Koshio; Keiichi Kajiwara; Koichi Ikizawa; Keiji Nakagami; Yukiyoshi Yanagihara
- Book ID
- 108930076
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 728 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1323-8930
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## Abstract ## Objective Stromal cell–derived factor 1 (SDF‐1) is a potent chemoattractant for memory T cells in inflamed rheumatoid arthritis (RA) synovium. This study was undertaken to investigate the effect of interleukin‐17 (IL‐17) and CD40–CD40L interaction on SDF‐1 production in RA fibroblas