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Blocking of α5 integrin stimulates production of TGF-β and PAI-1 by human mesangial cells

✍ Scribed by Naoki Matsumoto; Eiji Ishimura; Hidenori Koyama; Shinji Tanaka; Yasuo Imanishi; Atsushi Shioi; Masaaki Inaba; Yoshiki Nishizawa

Book ID: 117053964
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 138 KB
Volume: 305
Category: Article
ISSN: 0006-291X
DOI: 10.1016/s0006-291x(03)00860-x

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## Abstract During epidermal chemical carcinogenesis benign papillomas convert to squamous cell carcinomas, some of which undergo epithelial‐mesenchymal conversion to highly malignant spindle cell tumors. TGFβ inhibits early stages of carcinogenesis but promotes the spindle cell phenotype in later