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Blocking of syngeneic effector T cells by soluble tumour antigens

✍ Scribed by PLATA, FERNANDO; LEVY, JEAN PAUL

Book ID
109690422
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
399 KB
Volume
249
Category
Article
ISSN
0028-0836

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## Abstract Injection of a large number of tumour cells, like other strong immunogenic challenges, is followed within 6 h by the uptake of cytophilic Ig (probably complexes) by a subpopulation of T cells. This phenomenon, known as the β€œ6‐hour T‐cell response” is abrogated when small tumour cell ino

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## Abstract A large dose of tumour cells (10^7^) from two different tumours produced a significant increase of Ig‐bearing spleen cells 6 h after intraperitoneal administration in syngeneic mice, like conventional antigens previously tested. Incubation of normal spleen cells in serum taken 6 h after