Blocking L-type calcium channels enhances long-term depression induced by low-frequency stimulation at hippocampal CA1 synapses

Steroid pregnenolone sulfate enhances NM

Steroid pregnenolone sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses: Role for L-type calcium channels and sigma-receptors

✍ Jilla Sabeti; Thomas E. Nelson; Robert H. Purdy; Donna L. Gruol 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 539 KB

## Abstract Severe stress elevates plasma and CNS levels of endogenous neuroactive steroids that can contribute to the influence of stress on memory formation. Among the neuroactive steroids, pregnenolone sulfate (PREGS) reportedly strengthens memories and is readily available as a memory‐enhancing