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Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations

✍ Scribed by He, Biao; Reguart, Noemi; You, Liang; Mazieres, Julien; Xu, Zhidong; Lee, Amie Y; Mikami, Iwao; McCormick, Frank; Jablons, David M


Book ID
110069568
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
195 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Abstract Constitutive activation of the Wnt pathway as a result of __APC__, __AXIN1__ or __CTNNB1__ mutations has been found in most colorectal cancers. For a long time, this aberrant Wnt activation has been thought to be independent of upstream signals. However, recent studies indicate that ups