Blockade of the C5a receptor fails to protect against experimental autoimmune encephalomyelitis in rats
β Scribed by B. P. MORGAN; M. GRIFFITHS; H. KHANOM; S. M. TAYLOR; J. W. NEAL
- Book ID
- 108699006
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 388 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0009-9104
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## Abstract A substrain of the Lewis rat, Lew/Mol, differing from ordinary Lewis rats in that it is hardly susceptible to the induction of experimental autoimmune encephalomyelitis (EAE) is described. The Lew/Mol rats did not mount a hostβvs. βgraft response towards cells from an EAEβsusceptible su
## Abstract Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis that requires the activation of auto reactive T cells that infiltrate the central nervous system. In previous studies we have shown that intraperitoneal admin
Mutation of aspartate 82 of the human C5a receptor abolishes the secretory response to human C5a in transfected rat basophilic leukemia cells \* C5a is a potent chemoattractant for monocytes, neutrophils and other leukocytes. The receptor for human C5a is a member of the rhodopsin superfamily of G p