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Blockade of behavioral sensitization to cocaine and amphetamine by inhibitors of protein synthesis

✍ Scribed by Ralph Karler; Kevin T. Finnegan; Larry D. Calder

Book ID
115804308
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
546 KB
Volume
603
Category
Article
ISSN
0006-8993

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Sensitization to cocaine has been attributed to alterations in excitatory amino acid and dopamine neurotransmission in the mesolimbic system. The present study sought to determine whether inhibition of NAALADase, an enzyme that cleaves glutamate from the endogenous neuropeptide, N-acetyl-aspartyl-gl