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Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857)

✍ Scribed by Joseph N. Hingtgen; Ray W. Fuller; Norman R. Mason; M.H. Aprison


Book ID
118317091
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
365 KB
Volume
20
Category
Article
ISSN
0006-3223

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## Abstract F‐18 labeled SR46349B, a highly potent and selective 5‐HT~2~ receptor antagonist, was synthesized as a potential radioligand for PET studies of brain 5‐HT~2~ receptors. Nucleophilic aromatic substitution of __trans__‐1‐(2‐nitrophenyl)‐3‐(4‐methoxymethoxyphenyl)‐2‐propenone (10) with NCA