Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by β-amyloid peptide

Different protection of K252a and N-acet

Different protection of K252a and N-acetyl-L-cysteine against amyloid-β peptide–induced cortical neuron apoptosis involving inhibition of MLK3–MKK7–JNK3 signal cascades

✍ Yan Xu; Xiao-Yu Hou; Yong Liu; Yan-Yan Zong 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB

## Abstract Amyloid‐β peptide (Aβ) has been implicated in the etiopathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms underlying Aβ neurotoxicity remain to be elucidated. This study showed that Aβ treatment resulted in the increased phosphorylation (activation) of MLK3, MKK7