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Blockade by N-methylhydroxylamine or activation of guanylate cyclase and elevations of guanosine 3′,5′-monophosphate levels in nervous tissues

✍ Scribed by Deguchi, Takeo; Saito, MItsuo; Kono, Momoko


Book ID
123429693
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
735 KB
Volume
544
Category
Article
ISSN
0304-4165

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Activation of the guanylate cyclase-guan
✍ Frederick R. de Rubertis; Patricia A. Craven 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 979 KB

The effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the guanylate cyclase (GC)-guanosine 3'5' monophosphate (cGMP) system of rat colonic mucosa were studied. MNNG (1 mM) increased colonic mucosal cGMP from 1.8 f 03 to 22.5 f 2.7 pmol/mg protein in 5 minutes. Increases in response to MNNG o