Block-units method for conformational calculations of large nucleic acid chains. II. The two-hierarchical approach and its application to conformational arrangement of the unusual TψC loop of rabbit tRNAval
✍ Scribed by YU. N. Vorobjev
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1990
- Tongue
- English
- Weight
- 675 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
The two-level hierarchical methodology is suggested for conformational calculations of large fragments of nucleic acids. The method of the first level is intended for performing a fast screening of the conformational phase space. The high-level method may be used to refine structurally important conformations. The method of the first level is the blockunits method, which has been developed specially for these purposes (see part I ) . It has been shown that the block-units method allows the satisfactory calculation of the structure parameters of the optimal conformations of polynucleotides. The results of the conformational rearrangement calculations of the T+C loop of the tRNAPh' after modification of its sequence are represented. 259-283.