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Block of N-methyl-D-aspartate-Activated Current by the Anticonvulsant MK-801: Selective Binding to Open Channels

โœ Scribed by James E. Huettner and Bruce P. Bean

Book ID
123635159
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
964 KB
Volume
85
Category
Article
ISSN
0027-8424

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The novel anticonvulsant MK-801 binds to
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-d-aspartate receptor in rat brain
โœ Alan C. Foster; Erik H.F. Wong ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 1022 KB

The influence of endogenous and exogenous acidic amino acids on the binding of [3H]-MK-801, a selective, non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has been inves- tigated in rat cerebral cortex crude synaptic membranes (CSM). 2 Removal of endogenous glutamate and aspartate