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Block and Permeation of the Hypokalemic Periodic Paralysis Gating Pore In Nav1.4 Channels

โœ Scribed by Sokolov, Stanislav; Scheuer, Todd; Catterall, William A.


Book ID
122130793
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
39 KB
Volume
98
Category
Article
ISSN
0006-3495

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Electrophysiological studies on muscle fibres from patients with hyperkalemic periodic paralysis with myotonia have shown that the episodes of weakness are caused by a sustained depolarization of the sarcolemma to potentials between -40 and -60 mV. In muscle fibre segments from three such patients t