𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Blastic mantle cell leukemia: A previously undescribed form

✍ Scribed by Cherie H. Dunphy; John C. Hancock; Jack J. Rodriguez; Jack G. Hilton

Book ID
101270093
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
217 KB
Volume
13
Category
Article
ISSN
0887-8013

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✦ Synopsis

The leukemic phase of mantle cell lymphoma (mantle cell leukemia) is defined as an absolute lymphocyte count of greater than 4,000/microliter and characterized by the presence of relatively small, slightly irregular lymphocytes in the peripheral blood. Although a variant of mantle cell lymphoma with blastic morphsology exists and has been previously well described, a blastic morphologic variant of mantle cell leukemia has not been described. We report such a case in a 74-year-old male who presented with splenic rupture and an elevated white blood cell (WBC) count. The diagnosis was based on flow cytometric immunophenotyping and the cytomorphology of the peripheral blood.

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A B-cell chronic lymphoid leukemia (B-CLL) associated with IgA expression and secretion is uncommon and has never been described in association with osteolytic bone lesions. We report such a case, defined by cytomorphology and flow cytometric immunophenotyping (FCI). Additional cases may be recogniz