Bladder tumor induction by cytotoxic agents clinical experience and experimental data

Cytotoxicity, apoptosis induction and do

Cytotoxicity, apoptosis induction and downregulation of MDR-1 expression by the anti-topoisomerase II agent, salvicine, in multidrug-resistant tumor cells

✍ Ze-Hong Miao; Tao Tang; Yi-Xiang Zhang; Jin-Sheng Zhang; Jian Ding 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 332 KB 👁 1 views

## Abstract Salvicine, a novel topoisomerase II inhibitor and a diterpenoid quinone compound, exerts potent __in vitro__ and __in vivo__ antitumor effects. In our study, we show that salvicine effectively kills multidrug‐resistant (MDR) sublines, such as K562/A02, KB/VCR and MCF‐7/ADR, and parental