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Bladder carcinoma in Costello syndrome: Report on a patient born to consanguineous parents and review

✍ Scribed by Franceschini, P.; Licata, D.; Di Cara, G.; Guala, A.; Bianchi, M.; Ingrosso, G.; Franceschini, D.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 56 KB
Volume: 86
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19990910)86:2<174::aid-ajmg17>3.0.co;2-y

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✦ Synopsis

We report on a 12-year-old boy with Costello syndrome born to consanguineous (first cousins once removed) parents, supporting the hypothesis of recessive transmission of this syndrome. At age 11 years, the patient developed a bladder carcinoma, a rare pediatric tumor not previously described in Costello syndrome. This suggests that an increased risk of malignancy may be part of this condition.

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