Bisulfite methylation analysis of single DNA strands
β Scribed by Kimberly D. Tremblay
- Book ID
- 114393048
- Publisher
- Elsevier
- Year
- 1998
- Weight
- 93 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1366-2120
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## Abstract Epigenetic alterations of gene function play a central role in the pathogenesis of many tumors and in the process of aging. Abnormal methylation at transcriptional sites of genes results in epigenetic silencing of the genes that protect against tumor formation or that repair DNA. To dat
DNA methylation is an important epigenetic modification that alters transcription in those genes containing CpG islands. In this report, a novel DNA methylation analysis method was developed employing bisulfite-single strand conformation polymorphism combined with capillary electrophoresis (bisulfit