Bisphosphonates Induce Apoptosis of Stromal Tumor Cells in Giant Cell Tumor of Bone
β Scribed by Y. Y. Cheng; L. Huang; K. M. Lee; J. K. Xu; M. H. Zheng; S. M. Kumta
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 312 KB
- Volume
- 75
- Category
- Article
- ISSN
- 1432-0827
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## Abstract ## BACKGROUND The term __malignant giant cell tumor__ embraces multiple entities and therefore can be confusing. The goals of the current study were to define the clinicopathologic and histologic features of malignancy in giant cell tumors and to clarify the terminology. ## METHODS T
Giant cell tumor of bone is a progressive, potentially malignant process which destroys skeletal tissue by virtue of its osteoclast complement. As a biological entity it provides a unique natural model of bone resorption by osteoclasts whose recruitment and development is controlled by a neoplastic