Bisphosphonates' antitumor activity: An unravelled side of a multifaceted drug class

Antiparasitic and Antibacterial Drug Dis

Antiparasitic and Antibacterial Drug Discovery || Cyclooctadepsipeptides– An Anthelmintically Active Class of Compounds Exhibiting a Novel Mode of Action

✍ Selzer, Paul M. 📂 Article 📅 2009 🏛 Wiley-VCH Verlag GmbH & Co. KGaA ⚖ 250 KB

The High-Resolution Solution Structure o

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

The High-Resolution Solution Structure o

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

Antiangiogenic and Antitumoral Activity

Antiangiogenic and Antitumoral Activity of Phenyl-3-(2-Chloroethyl)Ureas: A Class of Soft Alkylating Agents Disrupting Microtubules That Are Unaffected by Cell Adhesion-Mediated Drug Resistance

✍ Petitclerc, E. 📂 Article 📅 2004 🏛 American Association for Cancer Research 🌐 English ⚖ 664 KB

36 Preclinical antitumor activity of alp

36 Preclinical antitumor activity of alpha-Cobratoxin, an alpha7-nicotinic receptor inhibitor, in human malignant mesothelioma: A potential drug against a fatal cancer disease?

✍ Russo, P.; Cesario, A.; Catassi, A.; Paolucci, M.; Ognio, E.; Michele, C.; Dona- 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 198 KB

ChemInform Abstract: Synthesis and Biolo

ChemInform Abstract: Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent.

✍ Qun Li; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views