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Bisphosphine-Catalyzed Mixed Double-Michael Reactions: Asymmetric Synthesis of Oxazolidines, Thiazolidines, and Pyrrolidines

✍ Scribed by Sriramurthy, Vardhineedi; Barcan, Gregg A.; Kwon, Ohyun


Book ID
117988390
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
53 KB
Volume
129
Category
Article
ISSN
0002-7863

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✍ Dieter Enders; Dominik P. Göddertz; Christian Beceño; Gerhard Raabe 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB 👁 2 views

## Abstract The domino Mannich/aza‐Michael reaction of γ‐malonate‐substituted α,β‐unsaturated esters with __N__‐protected arylaldimines has been achieved. Catalyzed by bifunctional thioureas, 2,5‐__cis__‐configured polysubstituted pyrrolidines are obtained in good to excellent yields (76–99%), enan