Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity

✍ Scribed by Masami Ishido; Yoshinori Masuo; Manabu Kunimoto; Syuichi Oka; Masatoshi Morita

• Book ID: 102381440
• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 395 KB
• Volume: 76
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.20050

✦ Synopsis

Abstract

We examined the effects of bisphenol A, an endocrine disruptor, on rat behavioral and cellular responses. Single intracisternal administration of bisphenol A (0.2‐20 μg) into 5‐day‐old male Wistar rats caused significant hyperactivity at 4–5 weeks of age. Rats were about 1.6‐fold more active in the nocturnal phase after administration of both 2 and 20 μg of bisphenol A than were control rats. The response was dose‐dependent. Based on DNA macroarray analyses of the midbrain, bisphenol A decreased by more than twofold gene expression levels of the dopamine D4 receptor at 4 weeks of age and the dopamine transporter at 8 weeks of age. Furthermore, bisphenol A decreased by more than twofold gene expression levels of the dopamine D4 receptor at 4 weeks of age and the dopamine transporter at 8 weeks of age. We conclude that bisphenol A affected central dopaminergic system activity, resulting in hyperactivity due most likely to a large reduction of tyrosine hydroxylase activity in the midbrain. © 2004 Wiley‐Liss, Inc.