Bismuth nitrate pentahydrate: a new and environmentally benign reagent for guanidylation of N-benzoylthioureas

✍ Scribed by Silvio Cunha; Byanka R de Lima; Aparecido R de Souza

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 129 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02067-6

✦ Synopsis

The bismuth nitrate-mediated guanidylation of N-benzoylthioureas was studied. This salt proved to be an effective guanylating reagent and allowed the obtention of N-benzoyl-guanidines in good yields. The methodology described is a promising alternative to the use of toxic HgCl 2 in the synthesis of polysubstituted guanidines.