Bisleucocurine A, a novel bisindole alkaloid from Leuconotis griffithii

✍ Scribed by Alfarius E. Nugroho; Yusuke Hirasawa; Takahiro Hosoya; Khalijah Awang; A. Hamid A. Hadi; Hiroshi Morita

• Book ID: 104097550
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 307 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.02.126

✦ Synopsis

A novel bisindole alkaloid, bisleucocurine A (1), consisting of two strychnan skeletons with an N-1-C-17 0 and a C-12-C-2 0 bridges, was isolated from the leaves of Leuconotis griffithii and the structure was elucidated on the basis of spectroscopic data. Bisleucocurine A (1) showed cytotoxicity against various human cancer cell lines.