✦ LIBER ✦
Bis(hydroxymethyl)phosphinic acid analogues of acyclic nucleosides; synthesis and incorporation into short DNA oligomers
✍ Scribed by B Nawrot; O Michalak; M Nowak; A Okruszek; M Dera; W.J Stec
- Book ID
- 104251483
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 85 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Novel analogues of acyclic nucleosides based on a bis(hydroxymethyl)phosphinic acid (BHPA) backbone were obtained by condensation of the bis(4,4%-dimethoxytrityl) derivative of BHPA with N-1-or N-3-(2-hydroxyethyl)thymine in the presence of MSNT, or by an Appel reaction with N-1-or N-3-(2-aminoethyl)thymine. After selective deprotection and phosphitylation they were used as monomers for automated solid support synthesis of short oligomers by the phosphoramidite approach.