Bischler-napieralski reaction—II : Synthesis of some ketonic isoquinolines

✍ Scribed by Nobuo Itoh; Shigehiko Sugasawa

• Book ID: 104212010
• Publisher: Elsevier Science
• Year: 1959
• Tongue: French
• Weight: 52 KB
• Volume: 1
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)70287-5

✦ Synopsis

Ethylene ketals of the type (I) cyclise in presence of phosphorus pentoxide in pyrid& to give the ketal (II) which on hydrolysis yields l-phenyl-6:7-dimethoxy4oxo-3:4-dihydroisquinob (III). 1-(4-oxo-cyclohexyl)-6:7-dimethoxy-3:4-dihydroisoquinoline (Vlll) and 2-oxo-3-methyl-g:1& dimethoxy-I 2:3:4:6:7-hexahydro-1 lbH-benzo[a]-quinolizine (XV) were also synthesised.