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Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

✍ Scribed by Jing Liu; Wing-Lok Ho; Nelson Tze-Kin Lee; Paul R Carlier; Yuan-Ping Pang; Yi-Fan Han

Book ID: 117470575
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 198 KB
Volume: 282
Category: Article
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(00)00905-8

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## Abstract The current study aims to develop a specific and sensitive LC‐MS/MS method for determination of bis(7)‐tacrine (B7T) in rat plasma. A 100 µL plasma sample was extracted with ethyl acetate. B7T and the internal standard (IS), pimozide, in the samples were then analyzed with LC‐MS/MS in p