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Bis-(p-nitrophenylethyl)phosphoromonochloridate, a new versatile phosphorylating agent

โœ Scribed by Frank Himmelsbach; Wolfgang Pfleiderer


Book ID
104219725
Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
189 KB
Volume
23
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Nucleotides. Part XXVII Bis[2-(p-nitroph
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A new, versatile phosphorylating agent, bis [2-0,-nitrophenyl)ethyl] phosphorochloridate (3), has been prepared and is used for 3'-and/or 5'-phosphorylations of nucleosides. The resulting bis[2-@-nitrophenyl)ethyl] phosphotriesters are versatile synthons in oligonucleotide synthesis leading finally

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## Abstract N, Nโ€diisopropylโ€bis(4โ€chlorobenzyl) phosphoramidite is an easily accessible phosphitylating agent, which readily phosphorylates Bocโ€Serโ€OMe, Bocโ€Thrโ€OMe and Bocโ€Tyrโ€OMe in good to high yields after __t__โ€BuOOH or MCPBA oxidation. The Bocโ€group can be removed without affecting the phosp