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Bis-naphthalimides. 2. Synthesis and biological activity of 5,6-acenaphthalimidoalkyl-1,8-naphthalimidoalkyl amines

✍ Scribed by MF Braña; JM Castellano; M Morán; MJ Pérez de Vega; XD Qian; CA Romerdahl; G Keilhauer


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
360 KB
Volume
30
Category
Article
ISSN
0223-5234

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The synthesis of N,"-bis- (2-[(5-bromo-2-[ 1-14CIhexyl-1H-benz[de]isoquinolin-1,3(2H)-dion-6-yl)amino]ethyl}hexanediamide from 1-[ l-14C]-hexylamine and 4chloro-1 &naphthalic anhydride is described. The anhydride is first converted to the 4-chloro-N-[ 1-14C]hexyl-l,8-naphthalimide (2) by condensatio