Bipyridyl-based diphosphine as an efficient ligand in the rhodium-catalyzed asymmetric conjugate addition of arylboronic acids to α,β-unsaturated ketones

✍ Scribed by Qian Shi; Lijin Xu; Xingshu Li; Xian Jia; Ruihu Wang; Terry T.-L. Au-Yeung; Albert S.C. Chan; Tamio Hayashi; Rong Cao; Maochun Hong

• Book ID: 104254196
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 144 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01592-2

✦ Synopsis

Reactions of a,b-unsaturated ketones with excess arylboronic acids in the presence of a rhodium catalyst generated in situ from Rh(acac)(C 2 H 4 ) and (S)-P-Phos in dioxane/water at 100°C gave high yields of the corresponding products in up to 99% ee.