✦ LIBER ✦

Bipolar disorder and chromosome 18: An analysis of multiple data sets

✍ Scribed by Judith A. Badner; Lynn R. Goldin

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 29 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<569::aid-gepi3>3.0.co;2-v

No coin nor oath required. For personal study only.

✦ Synopsis

There have been conflicting reports of linkage between bipolar disorder and chromosome 18. We have analyzed five separate data sets using the two-point affected sib-pair method and family based association methods. We have found evidence of linkage in multiple data sets and differences in maternal and paternal allele sharing. Suggestive, though nonsignificant, evidence of linkage disequilibrium of two tightly linked markers has also been demonstrated in multiple data sets.

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