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Biphenotypic acute leukemia with b2a2 fusion transcript and trisomy 21

โœ Scribed by Tae Sung Park; Seung Tae Lee; Jaewoo Song; Kyung-A. Lee; Juwon Kim; Yongjung Park; Sungwook Song; Jong Rak Choi


Book ID
113513460
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
149 KB
Volume
188
Category
Article
ISSN
0165-4608

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TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence