✦ LIBER ✦
Biphasic modulation of protein kinase C (PKC) activity by polychlorinated dibenzo-p-dioxins (PCDDs) in serum-deprived rat aortic smooth muscle cells
✍ Scribed by Weber, Thomas J. ;Ou, Xiaolan ;Merchant, Mark ;Wang, Xiaohong ;Safe, Stephen H. ;Ramos, Kenneth S.
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 790 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0887-2082
No coin nor oath required. For personal study only.
✦ Synopsis
not altered. Prolonged exposure of SMCs to 10 nM TCDD, TCDF, and DCDD for 24 hours decreased PKC activity in the cytosolic fraction, while only TCDD and TCDF decreased particulate PKC activity. These data show that PKC activity is modulated differentially as a function of time in SMCs exposed to TCDD and related compounds. Collectively, the patterns of histone phosphorylation induced by these chemicals in rat aortic SMCs sug- gest that modulation of C-kinase activity involves both receptor-independent and receptor-related events.