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Biphasic inhibition of voltage-dependent cardiac sodium currents by isoproterenol

✍ Scribed by Bernd Schubert; Antonius M.J. VanDongen; Glenn E Kirsch; Arthur M Brown

Book ID
115981837
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
106 KB
Volume
22
Category
Article
ISSN
0022-2828

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Voltage-dependent regulation of L-type c
Voltage-dependent regulation of L-type cardiac Ca channels by isoproterenol
✍ FranΓ§ois Tiaho; JoΓ«l Nargeot; Sylvain Richard πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 753 KB

The beta-adrenergic cascade is important for the regulation of voltage-dependent Ca channels by phosphorylation. Here we report that isoproterenol (ISO) profoundly alters the voltage-dependent properties of L-type Ca channels studied in rat ventricular cells. ISO (1 microM) shifted both threshold an