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Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes

✍ Scribed by Müller, W.E.G.; Sobel, C.; Sachsse, W.; Diehl-Seifert, B.; Zahn, R.K.; Eich, E.; Kljajić, Z.; Schröder, H.C.

Book ID
121000160
Publisher
Elsevier Science
Year
1986
Weight
519 KB
Volume
22
Category
Article
ISSN
0277-5379

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✍ M. Ramanadham; Milton Kern 📂 Article 📅 1983 🏛 Springer 🌐 English ⚖ 365 KB

The effect of sodium orthovanadate on enhancement of DNA synthesis by T and B cell mitogenic agents was studied using murine thymocytes and splenocytes. Addition of vanadate to thymocyte cultures inhibited the mitogenic response induced by concanavalin A in a dose dependent manner (50% inhibition at