Biotransformation studies on 1-chloro-2, 3-propanediol dinitrate
โ Scribed by Albert J. Dietz Jr.
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 223 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
1,2-and 1,3-glyceryl dinitrates (1,2-GDN and 1,3-GDN) are the primary metabolites of glyceryl trinitrate, a commonly used anti-anginal agent. The goal of this study was to examine the pharmacokinetic properties of these metabolites in rats. Sprague-Dawley rats were infused intravenously with 0.25 or
## Abstract BACKGROUND: An indirect solventโfree synthetic approach for obtaining glycerol carbonate and glycidol from glycerol and CO~2~ through their more reactive and easily synthesizable derivatives 3โchloroโ1,2โpropanediol (HAL) and potassium (hydrogen) carbonate has been studied. RESULTS: Th