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Biotransformation of triptolide by Cunninghamella blakesleana

✍ Scribed by Lili Ning; Jixun Zhan; Guiqin Qu; Lei Zhong; Hongzhu Guo; Kaishun Bi; Dean Guo

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
117 KB
Volume
59
Category
Article
ISSN
0040-4020

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✦ Synopsis

Biotransformation of triptolide 1 by Cunninghamella blakesleana (AS 3.970) was carried out. Seven biotransformation products were obtained and four of them were characterized as new compounds. On the basis of their NMR and mass spectral data, their structures were characterized as 5a-hydroxytriptolide 2, 1b-hydroxytriptolide 3, triptodiolide 4, 16-hydroxytriptolide 5, triptolidenol 6, 19a-hydroxytriptolide 7 and 19b-hydroxytriptolide 8. All the new transformed products (2, 3, 7 and 8) were found to exhibit potent in vitro cytotoxicity against some human tumor cell lines.

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