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Biotransformation of caffeine by microsomes from human liver: Kinetics and inhibition studies

โœ Scribed by Denis M. Grant; Monica E. Campbell; Bing K. Tang; Werner Kalow


Book ID
115779463
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
1021 KB
Volume
36
Category
Article
ISSN
0006-2952

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The 6-hydroxylation of chlorzoxazone (CLZ) is currently being used in both in vivo and in vitro studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans. Comparatively little is known with regard to the biotransformation of this drug in other species. The NADPH-dependent biotransformation