Biotin–Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica

✍ Scribed by Axel Schlossbauer; Johann Kecht; Thomas Bein

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 373 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200805818

✦ Synopsis

Abstract

Tell your guests when it's time to go: When avidin caps are attached to biotinylated colloidal mesoporous silica, the four subunits of the protein avidin can each bind to a biotin moiety attached to the surface (see picture). The resulting material is a promising candidate for the design of smart detergents or drug‐delivery systems. The caps can be opened to release guest molecules by controlled enzymatic hydrolysis of the protein.magnified image